In FFG project „EIS for Fabs“ we develop a novel biosensor based on electrochemical impedance spectroscopy (EIS) to 1) monitor Fab production processes in bioreactors in real-time, and 2) quantify Fabs in the different unit operations during product purification, thus allowing in-process-control (IPC).
Antibody fragments (Fabs) are extremely relevant biopharmaceutical molecules. Usually, Fabs are produced in the periplasm of E. coli. However, a well-known phenomenon during such production processes is cell-leakiness, the loss of cell integrity. This leakiness cannot be detected in real time, but only by offline and time-delayed ELISA analytics – you know about leakiness only when the process is already over. Another challenge in Fab production is their purification and the quantification of product in the numerous downstream unit operations.
You will work in a team with 2 PhD students and a technician and work on different aspects of
1) Biosensor Design and Engineering, 2) Data Science and Modeling, 3) Upstream,
4) Downstream, and 5) Analytics.
You have studied (electro)chemistry, chemical engineering, bioprocess technology, or similar. You are experienced in electrochemistry and data science. Moreover, you are able to work independently as well as in a team. The ability to meet timelines as well as good written and verbal communication in English are part of your qualifications. You are willing to supervise students and assist in teaching.
Dates & Salary
The position is available from 01. November 2020 and is scheduled for 1.5 years.
Applications are welcome until October 31st, 2020.
The salary is 14x € 3,889 gross per year.